When Reason, Conscience, and Light Are Abandoned What Is a Reprobate Mind? A reprobate mind, as described in Romans 1:28, is a state of depravity and corruption—an “unapproved” mind, surrendered by God to its own sinful desires after it willfully rejects Him. Derived from the Greek term adokimos (meaning “worthless,” “rejected,” or “failed the test”), it signifies a profound moral…